EPIGENETICS – HACKING OUR HEALTH BY UNRAVELLING OUR EPIGENETIC OUTPUT
Dear Wellness Seeker,
Chenot Molecular Lab Identifies and Optimizes Your Epigenetic Profile Status for Optimal Living
Is ageing an inevitable natural process that should be accepted, or is it a pathology that should be regarded as a disease that could be reversed?
The concept of ageing is currently undergoing rapid advancement in the medical and biotechnology fields. Intensive research hopes to decipher and provide answers on specific therapies capable of preventing the onset of age-related symptoms.
In addition to our chronological age (the passage of time), there is also our biological age which reflects the age we are inside.
Biological ageing is characterised by a progressive functional decline at the molecular, cellular, tissue and organ levels. With ageing comes fragility, and as a consequence, an individuals’ susceptibility to disease and premature death increases. Presently, ageing is distinguished into two categories: primary ageing representing innate maturational processes (i.e., loss of melanin – grey hair), and secondary ageing, representing the effects of the environment, lifestyle choices and disease (i.e., diabetes, neurodegeneration, osteoporosis).
Through evolution and advancements in medicine, the life expectancy of humans has increased significantly. Although our life span has been extended, our health span has not, with most of the ageing population from 60 years and above developing at least one type of age-related chronic disease due to secondary ageing-related factors. A main reason for the above is the emphasis in our social norm to visit our health care practitioner only when symptoms such as pain, disbalance, and Inflammation are experienced. In addition, the healthcare system focuses on treating and providing medication when these symptoms start to occur. Currently, medication is prescribed on a common basis for everybody and predominantly focuses only on suppressing symptoms. It does not reverse all age-related problems and does not address the cause of the problem(s). It is only recently that preventative medicine has made advancements on addressing the root cause of age-related diseases to prevent the onset of maladaptive symptoms in later life – thus, extending life span whilst also synergistically extending the longevity of our health and wellbeing.
Preventative medicine aims to incorporate all the above by applying science to people, specifically at the molecular level as a way of pre-screening for diseases that may arise in later life. Existing studies in animal research and now more recently in human epidemiology, have demonstrated a difference in biological and chronological ageing. By assuming that secondary ageing diseases are malleable, this allows the formulation of specific treatment plans according to the individuals’ results to target and build resilience to the onset of maladaptive symptoms thereby reducing the need for medicinal interference and medicinal reliance in later life.
While our genetic profile (DNA) is invaluable to determine our predisposition to disease, it does not reveal any information about the real-time functional status of a cell. DNA analysis provides us only with a static picture of the genetic information that a cell/ organism carries, but it does not allow us to quantify gene activity.
It is the influence of epigenetic factors such as our environment, diet, exercise, drugs, disease/toxin exposure and psychological state that change the expression and activity of our genes that causes them to turn ‘’on’’ and ‘’off’’. Therefore, it is easy to see the connection between our genes, and these epigenetic factors.
To achieve the above, advancements in molecular sciences have developed breakthrough research, the principle of which shows that each individual is unique at the molecular level and should be managed on a personalised basis. Novel molecular tests focusing especially on gene expression are developed, in order to further understand and quantify age-related disease, predispositions and associated risk. Emerging research has shown that this can be attained by using the RNA from blood samples and/or other biological fluids.
The Chenot Molecular Lab was created for a specific purpose: to monitor and measure gene activation, behaviour and expression to pre-screen for disease and illness that may arise in later life. Each person is unique at the molecular level, and the approach to disease and illness prevention should be personalized accordingly.
By performing gene expression analysis for certain genes, at the state-of-the-art molecular lab within Chenot Palace Weggis, we are able to evaluate gene activity for each guest and most importantly, monitor changes for these genes before and after the applied treatment protocols. The methodology used to study the expression of genes is quantitative real-time PCR.