World's Best Detox Programme for the fifth consecutive year
Detoxification: the foundation that creates Health
Chenot Palace Weggis
Five years at No.1 in detoxification. One clear reason.
By activating cellular pathways rooted in autophagy and re-awakening the body’s natural repair systems, it performs better, ages more slowly, and feels lighter — both mentally and physically. Our approach has just been named World’s Best Detox Programme 2025 for the fifth consecutive year, and a new scientific study confirms why the Chenot Diet® works.
Detoxification as Cellular Cleanup
For more than five decades, Chenot has placed detoxification at the core of its philosophy. Detoxification is the foundation of renewal, the representing the driving force addressing the twelve hallmarks of aging as well as aging-related cell damage and dysfunction.
By clearing debris and dysfunctional cells, the body regains its ability to repair, regenerate and thrive. Every day, cells generate waste products as part of normal metabolism. In youth, this waste is efficiently recycled through autophagy—a housekeeping process that removes damaged proteins, faulty mitochondria and other toxic build-up. This ongoing cleanup keeps tissues strong, mitochondria efficient, the immune system sharp, and the brain clear.
Over time, however, this recycling becomes less effective. Damaged components accumulate, senescent cells build up, and mitochondrial efficiency declines. These changes not only drive physical ageing but also fuel inflammation, fatigue, cognitive decline and chronic disease. In this way, the failure of cellular detoxification becomes a root cause of both physical and mental deterioration.
Detoxification at Chenot goes far beyond diet. It is a systemic reset designed to optimise every layer of cellular and physiological function, including:
- Structured fasting & FMD — activating autophagy and renewal.
- Hydrotherapy and heat treatments — stimulating circulation, lymphatic drainage and toxin elimination. These treatments also induce the activation of heat shock proteins (HSPs), pivotal in mediating autophagy-related benefits and cellular protection.
- Bioenergetic therapies — harmonising the autonomic nervous system to restore equilibrium.

The science behind Chenot
The new clinical study reveals the unique benefits of Chenot’s plant-based fasting-mimicking diet:
- Lower IGF-1: Levels decreased, a change associated with slower biological ageing.
- Higher ketones: Beta-hydroxybutyrate (BHB) rose, indicating a flexible, fat-burning metabolism on low-calorie days.
- More cellular clean-up: Markers of autophagy increased — the body’s process for clearing damaged cell components.
- Longevity genes upregulated: Increased activity of SIRT1 and FOXO1, linked to cellular repair and healthy ageing.
The findings reinforce Chenot’s position at the forefront of evidence-based wellness, with measurable effects on the key biomarkers of longevity.
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Find out more about our award winning programmes and book your next stay in one of our facilities.
Detox Programme
Our signature Chenot programme aims to induce a deep purification and detoxification of the body to eliminate toxins, increase vitality, reset energy levels and rebalance its physiology.
CHF 5’500
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CHF 6’400
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Chenot’s most intense health span enhancing programme combining our signature detox with high-impact rejuvenation to delay the onset of biological ageing.
CHF 7’100