DISCOVERY OF UROLITHIN
A crucial factor in harnessing the health benefi ts obtained from an optimal and healthy diet is the gut microbiome, a universe of trillions of bacteria that line the human gut and exist in a symbiotic relationship with us. Often, the positive eff ects of certain dietary components on health and longevity are found to be directly linked to the gut microbiota playing a crucial role. Timeline, along with top researchers at the Swiss Institute of Technology in Lausanne, Switzerland have discovered that certain compounds derived from plant-based foods could be converted by gut bacteria into Urolithin A, a nutrient with unique properties and potential benefi ts on both cellular and mitochondrial health. After 15 years of research, Timeline launched the fi rst and only clinically studied Urolithin A supplement, Mitopure®. Urolithin A is a postbiotic, which means we don’t get it directly from food. Rather we rely on our gut microbiome to make it from the foods that we eat. In the case of Urolithin A, our gut microbiome makes it after we consume ellagitannins – polyphenols found in pomegranates, nuts, and berries. It is then absorbed into the bloodstream and distributed to diff erent tissues, including mitochondria within cells. What makes Urolithin A unique is its ability to trigger mitophagy, and it is the only nutrient clinically shown to induce mitophagy in humans.